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Article

Polymorphisms in PARP, IL1B, IL4, IL10, C1INH, DEFB1, and DEFA4 in meningococcal disease in three populations.

Shock (Augusta, Ga.) - 1 Jul 2010

Emonts Marieke, Vermont Clementien L, Houwing-Duistermaat Jeanine J, Haralambous Elene, Gaast-de Jongh Christa E, Hazelzet Jan A, Faust Saul N, Betts Helen, Hermans Peter W M, Levin Michael, de Groot Ronald

Abstract excerpt

The pathogenesis of meningococcal infections involves activation of the complement system, proinflammatory and anti-inflammatory mediators, antimicrobial peptides, and apoptosis. We hypothesized that variations in genes encoding these products are involved in the susceptibility to and severity of pediatric meningococcal infections. Polymorphisms in poly (adenosine diphosphate-ribose) polymerase (PARP), serine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20016407
DOI: 10.1097/SHK.0b013e3181ce2c7d

Genes

DEFB1
DEFA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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