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Article

The potent anti-HIV activity of CXCL12gamma correlates with efficient CXCR4 binding and internalization.

Journal of virology - 1 Mar 2010

Altenburg Jeffrey D, Jin Qingwen, Alkhatib Bashar, Alkhatib Ghalib

Abstract excerpt

We previously demonstrated that the naturally occurring splice variant stromal cell-derived factor 1gamma/CXCL12gamma is the most potent CXCL12 isoform in blocking X4 HIV-1, with weak chemotactic activity. A conserved BBXB domain (B for basic and X for any residue) located in the N terminus ((24)KHLK(27)) is found in all six isoforms of CXCL12. To determine whether the potent antiviral activity of CXCL12gamma is...

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Share to Amino Acid Sequence
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Share to Chemokine CXCL12

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Protein Structure, Tertiary

Share to Receptors, CXCR4

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Source

Open in PubMed Open full text

Identifiers

PMID: 20015992
DOI: 10.1128/JVI.00342-09
PMCID: PMC2820898

Genes

CXCR4
CXCL12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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