Article
Ketoprofen, peginterferon 2a and ribavirin for genotype 1 chronic hepatitis C: a phase II study.
World journal of gastroenterology - 21 Dec 2009
Gramenzi Annagiulia, Cursaro Carmela, Margotti Marzia, Balsano Clara, Spaziani Alessandra, Anticoli Simona, Loggi Elisabetta, Salerno Maddalena, Galli Silvia, Furlini Giuliano, Bernardi Mauro, Andreone Pietro
Abstract excerpt
AIM: To evaluate the safety of adding ketoprofen to pegylated-interferon (PEG-IFN) with or without ribavirin and the effect on viral kinetics, STAT1 activity and expression of 2'-5'-oligoadenylate synthetase (2'-5'OAS) in genotype 1 chronic hepatitis C in a phase II study. METHODS: Forty-five patients were studied: fifteen were randomized to PEG-IFN plus ribavirin (PR), 16 to PEG-IFN plus ketoprofen and 14 to PR...
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