Back to search

Article

Safety and pharmacodynamics of intranasal administration of recombinant human interferon alfa-2b as a potential prophylactic for SARS-CoV-2 infection in an at-risk group: a phase I-II clinical trial, open, uncontrolled, in a single-arm (OLIVO Study)

2024-11-06

Abstract excerpt

<title>Abstract</title> <p>Type I interferons (IFN α and β) represent a promising potential candidate for the development of a broad-spectrum antiviral therapy in the event of a global viral outbreak. This study aimed to investigate the safety of intranasal administration of recombinant human interferon alpha 2b (Nasalferon) in order to characterize adverse events and to determine the gene expression levels of th...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
8dc4555d-02ae-570a-8bf2-6934b72a76b5
DOI
10.21203/rs.3.rs-5271166/v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Safety and pharmacodynamics of intranasal administration of recombinant human interferon alfa-2b as a potential prophylactic for SARS-CoV-2 infection in an at-risk group: a phase I-II clinical trial, open, uncontrolled, in a single-arm (OLIVO Study)DOI 10.21203/rs.3.rs-5271166/v1
Safety, tolerability, bioavailability, and biological activity of inhaled interferon-α2b in healthy adults: The IN2COVID phase 1 randomized trialSemantic proximity
Effect of combination of interferon alpha-2b and interferon-gamma or interferon alpha-2b alone for elimination of SARS-CoV-2 viral RNA. Preliminary results of a randomized controlled clinical trialSemantic proximity
Therapeutic effectiveness of interferon-alpha 2b against COVID-19: the Cuban experienceSemantic proximity
Repurposing NASVAC, a hepatitis B therapeutic vaccine, for pre- and postexposure prophylaxis of SARS-CoV-2 infectionSemantic proximity
Interferon alpha-based combinations suppress SARS-CoV-2 infection in vitro and in vivoSemantic proximity
IFN-λ1 Displays Various Levels of Antiviral Activity In Vitro in a Select Panel of RNA VirusesSemantic proximity
Nirmatrelvir/ritonavir and molnuipiravir in the treatment of mild/moderate COVID-19: results of a real-life studySemantic proximity
Interferon Gamma Therapy in a Novel Case of Homozygous Interferon Alpha/beta Receptor Alpha Chain (IFNAR1) Deficiency Infected With SARS-CoV-2Semantic proximity
Phase II randomized controlled trial to evaluate the efficacy and safety of HeberFERON versus Heberon alpha R in symptomatic or asymptomatic patients infected with the SARS-CoV-2 (Study ESPERANZA/HOPE).Semantic proximity
Characterization of the antiviral effects of interferon-α against a SARS-like coronoavirus infection in vitroSemantic proximity
A phase 2 study to evaluate the antiviral activity, safety, and pharmacokinetics of recombinant human albumin-interferon alfa fusion protein in genotype 1 chronic hepatitis C patients.Semantic proximity
Effectiveness of alpha interferon (+ ribavirin) in the treatment of chronic viral hepatitis C genotypes 2 and 3 in a Brazilian sample.Semantic proximity
Select a neighboring publication to make it the new centre.