Article
Identification of common genetic variants that account for transcript isoform variation between human populations.
Human genetics - 1 Feb 2009
Zhang Wei, Duan Shiwei, Bleibel Wasim K, Wisel Steven A, Huang R Stephanie, Wu Xiaolin, He Lijun, Clark Tyson A, Chen Tina X, Schweitzer Anthony C, Blume John E, Dolan M Eileen, Cox Nancy J
Abstract excerpt
In addition to the differences between populations in transcriptional and translational regulation of genes, alternative pre-mRNA splicing (AS) is also likely to play an important role in regulating gene expression and generating variation in mRNA and protein isoforms. Recently, the genetic contribution to transcript isoform variation has been reported in individuals of recent European descent. We report here...
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