Clinical manifestations of α-thalassemia.

Abstract excerpt

α-Thalassemia mutations affect up to 5% of the world's population. The clinical spectrum ranges from an asymptomatic condition to a fatal in utero disease. Hemoglobin H disease results from mutations of three α-globin genes. Deletional forms result in a relatively mild anemia, whereas nondeletional mutations result in a moderate to severe disease characterized by ineffective erythropoiesis, recurrent...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Chronic Disease
• Share to Age of Onset
• Share to alpha-Thalassemia