Article

OPN promotes pro-inflammatory cytokine expression via ERK/JNK pathway and M1 macrophage polarization in Rosacea

2023-11-30

Abstract excerpt

<h4>Objective: </h4> Rosacea is a chronic inflammatory dermatosis that involves dysregulation of innate and adaptive immune systems. Osteopontin (OPN) is a phosphorylated glycoprotein produced by a broad range of immune cells such as macrophages, keratinocytes, and T cells. OPN is significantly elevated in the epidermis of rosacea patients. However, the role of OPN in rosacea remains to be elucidated. <h4>Methods...

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Literature Corpus work: e59743e6-6d34-517a-9cff-5efee1dc2943
DOI: 10.21203/rs.3.rs-3651651/v1

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