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Article

Systematic structure-function analysis of androgen receptor Leu701 mutants explains the properties of the prostate cancer mutant L701H.

The Journal of biological chemistry - 12 Feb 2010

van de Wijngaart Dennis J, Molier Michel, Lusher Scott J, Hersmus Remko, Jenster Guido, Trapman Jan, Dubbink Hendrikus J

Abstract excerpt

One mechanism of prostate tumors for escape from androgen ablation therapies is mutation of the androgen receptor (AR). We investigated the unique properties of the AR L701H mutant, which is strongly stimulated by cortisol, by a systematic structure-function analysis. Most amino acid substitution...

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Identifiers

PMID: 20007693
DOI: 10.1074/jbc.M109.039958
PMCID: PMC2836112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007693-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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