Article
A glucocorticoid-responsive mutant androgen receptor exhibits unique ligand specificity: therapeutic implications for androgen-independent prostate cancer.
Endocrinology - 1 May 2002
Krishnan Aruna V, Zhao Xiao-Yan, Swami Srilatha, Brive Lars, Peehl Donna M, Ely Kathryn R, Feldman David
Abstract excerpt
The cortisol/cortisone-responsive AR (AR(ccr)) has two mutations (L701H and T877A) that were found in the MDA PCa human prostate cancer cell lines established from a castrated patient whose metastatic tumor exhibited androgen-independent growth. Cortisol and cortisone bind to the AR(ccr) with high affinity. In the present study, we characterized the structural determinants for ligand binding to the AR(ccr). Our...
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