Article
Transient Epstein-Barr virus reactivation in CD3 monoclonal antibody-treated patients.
Blood - 11 Feb 2010
Keymeulen Bart, Candon Sophie, Fafi-Kremer Samira, Ziegler Anette, Leruez-Ville Marianne, Mathieu Chantal, Vandemeulebroucke Evy, Walter Markus, Crenier Laurent, Thervet Eric, Legendre Christophe, Pierard Denis, Hale Geoff, Waldmann Herman, Bach Jean-François, Seigneurin Jean Marie, Pipeleers Daniel, Chatenoud Lucienne
Abstract excerpt
Here we report a unique situation in which an early and synchronized Epstein-Barr virus (EBV) reactivation was induced by a 6-day course of treatment with a humanized CD3-specific monoclonal antibody in patients with recent onset of type 1 diabetes. The virologic and immunologic analysis demonstrated that this reactivation was transient, self-limited, and isolated, associated with the rapid advent of an...
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