Article
Markers of the p53 pathway further refine molecular profiling in high-risk endometrial cancer: A TransPORTEC initiative.
Gynecologic oncology - 1 Aug 2017
Edmondson R J, Crosbie E J, Nickkho-Amiry M, Kaufmann A, Stelloo E, Nijman H W, Leary A, Auguste A, Mileshkin L, Pollock P, MacKay H J, Powell M E, Bosse T, Creutzberg C L, Kitchener H C
Abstract excerpt
BACKGROUND: The morphological classification of high-risk endometrial cancer is of limited prognostic value. Recent attempts to stratify tumours according to molecular signatures have shown considerable promise. Here we attempted to further refine molecular classifications using markers of the p53 pathway. METHODS: We analysed the expression of p53 as well as three downstream markers of the p53 pathway, p21, mdm2...
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