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Article

Ubiquitination of tombusvirus p33 replication protein plays a role in virus replication and binding to the host Vps23p ESCRT protein.

Virology - 20 Feb 2010

Barajas Daniel, Nagy Peter D

Abstract excerpt

Post-translational modifications of viral replication proteins could be widespread phenomena during the replication of plus-stranded RNA viruses. In this article, we identify two lysines in the tombusvirus p33 replication co-factor involved in ubiquitination and show that the same lysines are also important for the p33 to interact with the host Vps23p ESCRT-I factor. We find that the interaction of p33 with...

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Identifiers

PMID: 20004458
DOI: 10.1016/j.virol.2009.11.010
PMCID: PMC2822108

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