Article
Polymorphisms in the vitamin A receptor and innate immunity genes influence the antibody response to rubella vaccination.
The Journal of infectious diseases - 15 Jan 2010
Ovsyannikova Inna G, Haralambieva Iana H, Dhiman Neelam, O'Byrne Megan M, Pankratz V Shane, Jacobson Robert M, Poland Gregory A
Abstract excerpt
BACKGROUND: Genetic polymorphisms play an important role in rubella vaccine-induced immunity. METHODS: We genotyped 714 healthy children after 2 age-appropriate doses of rubella-containing vaccine for 142 potential single-nucleotide polymorphisms (SNPs). RESULTS: Specific polymorphisms in the vitamin A receptor, retinoic acid-inducible gene I (RIG-I), and tripartite motif 5 and 22 (TRIM5 and TRIM22) genes were...
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