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Article

Mutant metabolic enzymes are at the origin of gliomas.

Cancer research - 15 Dec 2009

Yan Hai, Bigner Darell D, Velculescu Victor, Parsons D Williams

Abstract excerpt

Mutations of the isocitrate dehydrogenase (IDH) metabolic enzymes IDH1 and IDH2 have been found to be frequent and early genetic alterations in astrocytomas and oligodendrogliomas. All mutations identified to date affect a single amino acid located within the isocitrate binding site (R132 of IDH1...

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Source

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Identifiers

PMID: 19996293
DOI: 10.1158/0008-5472.CAN-09-2650
PMCID: PMC2794981

Genes

IDH1
IDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19996293-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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