Article
Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor.
Nagoya journal of medical science - 1 Sept 2009
Gao Siqiang, Murakami Masashi, Ito Hiromi, Furuhata Ayako, Yoshida Kayo, Tagawa Yoko, Hagiwara Kazumi, Takagi Akira, Kojima Tetsuhito, Suzuki Motoshi, Banno Yoshiko, Nozawa Yoshinori, Murate Takashi
Abstract excerpt
The underlying mechanisms of oncogene-induced phospholipase D (PLD) activation have not been fully elucidated. The effect of the mutated-ras on PLD mRNA was examined using colon cancer cell lines as well as mock- and mutated ras-transfected NIH3T3 cells. Ras-mutation and activation were correlated, and cells with enhanced ras-activation showed increased PLD1 mRNA and protein. Analysis of the 5' PLD1 promoter...
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