Article
Binding of human growth hormone (GH)-variant (placental GH) to GH-binding proteins in human plasma.
The Journal of clinical endocrinology and metabolism - 1 Dec 1991
Baumann G, Dávila N, Shaw M A, Ray J, Liebhaber S A, Cooke N E
Abstract excerpt
Human GH-variant (hGH-V) is a natural GH analog arising from the hGH-V gene. It is expressed in the placenta and secreted into the maternal circulation during the second half of pregnancy. To gain information about its bioactivity in man, we examined the interaction of hGH-V with the high affinity GH-binding protein/receptor (GH-BP) in human plasma. hGH-V was equipotent with pituitary hGH (hGH-N) as a ligand for...
Topics
- Binding, Competitive
- Blood
- Chimera
- Genetic Variation
- Growth Hormone
- Humans
- Isomerism
- Placental Hormones
- Receptors, Somatotropin