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Article

Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells.

Proceedings of the National Academy of Sciences of the United States of America - 29 Dec 2009

Brachmann Saskia M, Hofmann Irmgard, Schnell Christian, Fritsch Christine, Wee Susan, Lane Heidi, Wang Shaowen, Garcia-Echeverria Carlos, Maira Sauveur-Michel

Abstract excerpt

NVP-BEZ235 is a dual PI3K/mTOR inhibitor currently in phase I clinical trials. We profiled this compound against a panel of breast tumor cell lines to identify the patient populations that would benefit from such treatment. In this setting, NVP-BEZ235 selectively induced cell death in cell lines...

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Identifiers

PMID: 20007781
DOI: 10.1073/pnas.0905152106
PMCID: PMC2799764

Genes

KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20007781-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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