Article
The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome.
Blood - 8 Apr 2010
Driscoll James J, Pelluru Dheeraj, Lefkimmiatis Konstantinos, Fulciniti Mariateresa, Prabhala Rao H, Greipp Philip R, Barlogie Bart, Tai Yu-Tzu, Anderson Kenneth C, Shaughnessy John D, Annunziata Christina M, Munshi Nikhil C
Abstract excerpt
Multiple myeloma (MM) is a plasma cell neoplasm that proceeds through a premalignant state of monoclonal gammopathy of unknown significance; however, the molecular events responsible for myelomagenesis remain uncharacterized. To identify cellular pathways deregulated in MM, we addressed that sumoylation is homologous to ubiquitination and results in the attachment of the ubiquitin-like protein Sumo onto target...
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