Article
Inhalation exposure in Drosophila mutagenesis assays: experiments with aliphatic halogenated hydrocarbons, with emphasis on the genetic activity profile of 1,2-dichloroethane.
Mutation research - 1 Feb 1991
Kramers P G, Mout H C, Bissumbhar B, Mulder C R
Abstract excerpt
A series of mutation experiments was carried out with Drosophila melanogaster using inhalation exposure. 1,2-Dichloroethane (DCE) and 1,2-dibromoethane (DBE) were active in the sex-linked recessive lethal assay (SLRLT), whereas dichloromethane, dibromomethane, 1,2-dichloropropane and 1,3-dichloropropane were not. Compared to DBE, DCE is a less potent mutagen in the SLRL system. For both compounds, there is no...
Topics
- Administration, Inhalation
- Animals
- Chromosome Mapping
- Dose-Response Relationship, Drug
- Drosophila
- Ethylene Dibromide
- Ethylene Dichlorides
- Gene Frequency
- Genes, Lethal
- Glutathione