Article
A recessive gene for primary vesicoureteral reflux maps to chromosome 12p11-q13.
Journal of the American Society of Nephrology : JASN - 1 Jul 2009
Weng Patricia L, Sanna-Cherchi Simone, Hensle Terry, Shapiro Ellen, Werzberger Alan, Caridi Gianluca, Izzi Claudia, Konka Anita, Reese Adam C, Cheng Rong, Werzberger Samuel, Schlussel Richard N, Burk Robert D, Lee Joseph H, Ravazzolo Roberto, Scolari Francesco, Ghiggeri Gian Marco, Glassberg Kenneth, Gharavi Ali G
Abstract excerpt
Primary vesicoureteral reflux (pVUR) is one of the most common causes of pediatric kidney failure. Linkage scans suggest that pVUR is genetically heterogeneous with two loci on chromosomes 1p13 and 2q37 under autosomal dominant inheritance. Absence of pVUR in parents of affected individuals raises the possibility of a recessive contribution to pVUR. We performed a genome-wide linkage scan in 12 large families...
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