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Article

Association of TGFBR2 polymorphism with risk of sudden cardiac arrest in patients with coronary artery disease.

Heart rhythm - 1 Dec 2009

Tseng Zian H, Vittinghoff Eric, Musone Stacy L, Lin Feng, Whiteman Dean, Pawlikowska Ludmila, Kwok Pui-Yan, Olgin Jeffrey E, Aouizerat Bradley E

Abstract excerpt

BACKGROUND: Transforming growth factor ss (TGFss) signaling has been shown to promote myocardial fibrosis and remodeling with coronary artery disease (CAD), and previous studies show a major role for fibrosis in the initiation of malignant ventricular arrhythmias (VA) and sudden cardiac arrest (SCA). Common single nucleotide polymorphisms (SNPs) in TGFss pathway genes may be associated with SCA. OBJECTIVE: We...

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Source

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Identifiers

PMID: 19959123
DOI: 10.1016/j.hrthm.2009.08.031
PMCID: PMC2789271

Genes

TGFBR2
CAD
SMAD1
SMAD3
SMAD6
TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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