Article
The anti-proliferative effect of heat shock protein 90 inhibitor, 17-DMAG, on non-small-cell lung cancers being resistant to EGFR tyrosine kinase inhibitor.
Lung cancer (Amsterdam, Netherlands) - 1 Feb 2012
Kobayashi Naruyuki, Toyooka Shinichi, Soh Junichi, Yamamoto Hiromasa, Dote Hideaki, Kawasaki Kensuke, Otani Hiroki, Kubo Takafumi, Jida Masaru, Ueno Tsuyoshi, Ando Midori, Ogino Atsuko, Kiura Katsuyuki, Miyoshi Shinichiro
Abstract excerpt
Acquired resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs), gefitinib and erlotinib, is frequently observed after initiation of TKIs therapy. Non-small-cell lung cancers (NSCLC) with activating EGFR mutations were reported to be sensitive to heat shock protein 90 (Hsp90) inhibitors regardless of the secondary TKI-resistant T790M mutation. We established EGFR-TKI resistant...
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