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Article

Pathway analysis of GWAS provides new insights into genetic susceptibility to 3 inflammatory diseases.

PloS one - 30 Nov 2009

Eleftherohorinou Hariklia, Wright Victoria, Hoggart Clive, Hartikainen Anna-Liisa, Jarvelin Marjo-Riitta, Balding David, Coin Lachlan, Levin Michael

Abstract excerpt

Although the introduction of genome-wide association studies (GWAS) have greatly increased the number of genes associated with common diseases, only a small proportion of the predicted genetic contribution has so far been elucidated. Studying the cumulative variation of polymorphisms in multiple genes acting in functional pathways may provide a complementary approach to the more common single SNP association...

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PMID: 19956648
DOI: 10.1371/journal.pone.0008068
PMCID: PMC2778995

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