Identification and quantitative distribution of eight analogues of naturally occurring fecapentaenes in human feces by high-performance liquid chromatography.

Abstract excerpt

Fecapentaenes, highly potent fecal mutagens originating from intestinal bacterial production, have been suggested to play an essential role in the initiation of colorectal cancer. Reviewing the data on fecapentaene occurrence in man, the applied methodologies for fecapentaene extraction and analysis appear to be very inconsistent. Therefore, we compared several methods and developed an optimal extraction and...

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