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Article

A conserved evolutionary mechanism permits Δ9 desaturation of very-long-chain fatty acyl lipids.

The Journal of biological chemistry - 7 Aug 2020

Cai Yuanheng, Yu Xiao-Hong, Chai Jin, Liu Chang-Jun, Shanklin John

Abstract excerpt

Δ9 fatty acyl desaturases introduce a cis-double bond between C9 and C10 of saturated fatty acyl chains. From the crystal structure of the mouse stearoyl-CoA desaturase (mSCD1) it was proposed that Tyr-104, a surface residue located at the distal end of the fatty acyl binding pocket plays a key role in specifying 18C selectivity. We created mSCD1-Y104G to test the hypothesis that eliminating this bulky side chain...

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Source

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Identifiers

PMID: 32527722
DOI: 10.1074/jbc.RA120.014258
PMCID: PMC7415989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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