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Article

Akt promotes Endocardial-Mesenchyme Transition

1 Jan 2009

Abstract excerpt

Endothelial to mesenchyme transition (EndMT) can be observed during the formation of endocardial cushions from the endocardium, the endothelial lining of the atrioventricular canal (AVC), of the developing heart at embryonic day 9.5 (E9.5). Many regulators of the process have been identified; however, the mechanisms driving the initial commitment decision of endothelial cells to EndMT have been difficult to...

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PMID: 19946410
DOI: 10.1186/2040-2384-1-2

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