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Article

The extended life span of Drosophila melanogaster eye-color (white and vermilion) mutants with impaired formation of kynurenine.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2010

Oxenkrug Gregory F

Abstract excerpt

Animal and human studies suggest that aging is associated with increased formation of kynurenine (KYN) from tryptophan (TRY). The rate-limiting factors of TRY-KYN metabolism are transmembrane transport of TRY, and activity of enzyme, TRY 2,3-dioxygenase (TDO2). Eye-color mutants, white (w1118) (impaired TRY transport) and vermilion (v48a and v2) (deficient TDO activity), were compared with wild-type Oregon-R...

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Identifiers

PMID: 19941150
DOI: 10.1007/s00702-009-0341-7
PMCID: PMC3013506

Genes

TDO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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