Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli Ulcer

23 Nov 2009

Abstract excerpt

Mycolactone A/B is a lipophilic macrocyclic polyketide that is the primary virulence factor produced by Mycobacterium ulcerans, a human pathogen and the causative agent of Buruli ulcer. In M. ulcerans strain Agy99 the mycolactone polyketide synthase (PKS) locus spans a 120 kb region of a 174 kb megaplasmid. Here we have identified promoter regions of this PKS locus using GFP reporter assays, in silico analysis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Mycobacterium research and diagnosis
Share to Pharmacological Effects of Natural Compounds
Share to Tuberculosis Research and Epidemiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 19936295
DOI: 10.1371/journal.pntd.0000553

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mycolactone Gene Expression Is Controlled by Strong SigA-Like Promoters with Utility in Studies of Mycobacterium ulcerans and Buruli UlcerPMID 19936295Read ↗

Giant plasmid-encoded polyketide synthases produce the macrolide toxin of <i>Mycobacterium ulcerans</i>Semantic proximity Read ↗

Buruli ulcerSemantic proximity Read ↗

Mycobacterium ulcerans and Other Mycolactone-Producing Mycobacteria Should Be Considered a Single SpeciesSemantic proximity Read ↗

On the origin of Mycobacterium ulcerans, the causative agent of Buruli ulcer.Semantic proximity Read ↗

Large sequence polymorphisms unveil the phylogenetic relationship of environmental and pathogenic mycobacteria related to Mycobacterium ulcerans.Semantic proximity Read ↗

Deciphering the genetic basis for polyketide variation among mycobacteria producing mycolactonesSemantic proximity Read ↗

Chemistry of mycolactones, the causative toxins of Buruli ulcerSemantic proximity Read ↗

Evolution of <i>Mycobacterium ulcerans</i> and Other Mycolactone-Producing Mycobacteria from a Common <i>Mycobacterium marinum</i> ProgenitorSemantic proximity Read ↗

Mycolactones: immunosuppressive and cytotoxic polyketides produced by aquatic mycobacteriaSemantic proximity Read ↗

Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection).Semantic proximity Read ↗

Functional analysis and annotation of the virulence plasmid pMUM001 from Mycobacterium ulceransSemantic proximity Read ↗

Two Group A Streptococcal Peptide Pheromones Act through Opposing Rgg Regulators to Control Biofilm DevelopmentSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.