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Article

Early-onset Crohn disease is associated with male sex and a polymorphism in the IL-6 promoter.

Journal of pediatric gastroenterology and nutrition - 1 Jan 2010

Sagiv-Friedgut Keren, Karban Amir, Weiss Batya, Shaoul Ron, Shamir Raanan, Bujanover Yoram, Reif Shimon, Boaz Mona, Shani Inbar, Levine Arie, Leshinsky-Silver Esther

Abstract excerpt

AIMS: Pediatric onset of Crohn disease (CD) is characterized by male sex predominance while adult-onset disease demonstrates female sex predominance. It has been postulated that this phenomenon may be genetically determined or due to an effect of estrogen on age of onset. Interleukin (IL)-6 modul...

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Source

Identifiers

PMID: 19934771
DOI: 10.1097/MPG.0b013e3181b7a6a4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19934771-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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