Article
Impaired S-phase arrest in acute myeloid leukemia cells with a FLT3 internal tandem duplication treated with clofarabine.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Dec 2009
Seedhouse Claire, Grundy Martin, Shang Shili, Ronan John, Pimblett Heather, Russell Nigel, Pallis Monica
Abstract excerpt
PURPOSE: Acute myeloid leukemia cells with an internal tandem duplication mutation of FLT3 (FLT3-ITD) have effective DNA repair mechanisms on exposure to drugs. Despite this, the phenotype is not associated with primary resistant disease. We show defects in the response of mutant FLT3 AML cells to the S-phase drug clofarabine that could account for the apparent contradiction. EXPERIMENTAL DESIGN: We studied...
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