A pH-responsive riboregulator.

doi:10.1101/gad.552209

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Article

A pH-responsive riboregulator.

Genes & development - 15 Nov 2009

Nechooshtan Gal, Elgrably-Weiss Maya, Sheaffer Abigail, Westhof Eric, Altuvia Shoshy

Abstract excerpt

The locus alx, which encodes a putative transporter, was discovered previously in a screen for genes induced under extreme alkaline conditions. Here we show that the RNA region preceding the alx ORF acts as a pH-responsive element, which, in response to high pH, leads to an increase in alx expression. Under normal growth conditions this RNA region forms a translationally inactive structure, but when exposed to...

Topics

Base Pairing
Conserved Sequence
Escherichia coli
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Hydrogen-Ion Concentration
Mutation
Nucleic Acid Conformation
RNA Precursors
RNA, Bacterial

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Identifiers

PMID: 19933154
DOI: 10.1101/gad.552209
PMCID: PMC2779765

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