Polymorphism located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia).

doi:10.1371/journal.pone.0005394

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Article

Polymorphism located between CPT1B and CHKB, and HLA-DRB11501-DQB10602 haplotype confer susceptibility to CNS hypersomnias (essential hypersomnia).

PloS one - 1 Jan 2009

Miyagawa Taku, Honda Makoto, Kawashima Minae, Shimada Mihoko, Tanaka Susumu, Honda Yutaka, Tokunaga Katsushi

Abstract excerpt

BACKGROUND: SNP rs5770917 located between CPT1B and CHKB, and HLA-DRB1*1501-DQB1*0602 haplotype were previously identified as susceptibility loci for narcolepsy with cataplexy. This study was conducted in order to investigate whether these genetic markers are associated with Japanese CNS hypersomnias (essential hypersomnia: EHS) other than narcolepsy with cataplexy. PRINCIPAL FINDINGS: EHS was significantly...

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PMID: 19404393
DOI: 10.1371/journal.pone.0005394
PMCID: PMC2671172

Genes

CHKB

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