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Article

Crohn's disease: the cold chain hypothesis.

Lancet (London, England) - 13 Dec 2003

Hugot Jean-Pierre, Alberti Corinne, Berrebi Dominique, Bingen Edouard, Cézard Jean-Pierre

Abstract excerpt

Crohn's disease is the result of an abnormal immune response of the gut mucosa triggered by one or more environmental risk factors in people with predisposing gene variations, including CARD15 mutations. Epidemiological data allow assessment of familial environmental risk factors related to western lifestyle, diet, bacteria, and domestic hygiene. All findings point to refrigeration as a potential risk factor for...

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Identifiers

PMID: 14683664
DOI: 10.1016/S0140-6736(03)15024-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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