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Article

African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping.

Annual review of genomics and human genetics - 1 Jan 2008

Campbell Michael C, Tishkoff Sarah A

Abstract excerpt

Comparative studies of ethnically diverse human populations, particularly in Africa, are important for reconstructing human evolutionary history and for understanding the genetic basis of phenotypic adaptation and complex disease. African populations are characterized by greater levels of genetic diversity, extensive population substructure, and less linkage disequilibrium (LD) among loci compared to non-African...

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Identifiers

PMID: 18593304
DOI: 10.1146/annurev.genom.9.081307.164258
PMCID: PMC2953791

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