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Antitumor Effects of PRIMA-1 and PRIMA-1Met (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?

Cells - 7 Jan 2021

Menichini Paola, Monti Paola, Speciale Andrea, Cutrona Giovanna, Matis Serena, Fais Franco, Taiana Elisa, Neri Antonino, Bomben Riccardo, Gentile Massimo, Gattei Valter, Ferrarini Manlio, Morabito Fortunato, Fronza Gilberto

Abstract excerpt

Because of its role in the regulation of the cell cycle, DNA damage response, apoptosis, DNA repair, cell migration, autophagy, and cell metabolism, the TP53 tumor suppressor gene is a key player for cellular homeostasis. TP53 gene is mutated in more than 50% of human cancers, although its overall dysfunction may be even more frequent. TP53 mutations are detected in a lower percentage of hematological...

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Identifiers

PMID: 33430525
DOI: 10.3390/cells10010098
PMCID: PMC7827888

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Antitumor Effects of PRIMA-1 and PRIMA-1Met (APR246) in Hematological Malignancies: Still a Mutant P53-Dependent Affair?PMID 33430525Read ↗

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