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Article

PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.

1 Jan 2008

Abstract excerpt

Reactivation of the tumor suppressor activity to mutant p53 should trigger massive apoptosis and eliminate tumors. The low molecular weight compounds PRIMA-1 and the structural analog PRIMA-1MET reactivate human mutant p53 in vitro and suppress growth of human tumor xenografts in SCID mice. However, little is known about their effect on mouse mutant p53 in mouse tumor cells. We have examined the effect of...

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PMID: 18791272
DOI: 10.3233/clo-2008-0440

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PRIMA-1MET inhibits growth of mouse tumors carrying mutant p53.PMID 18791272Read ↗

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Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.Semantic proximity Read ↗

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PRIMA-1 inhibits growth of breast cancer cells by re-activating mutant p53 protein.Semantic proximity Read ↗

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Mutant p53 reactivation by PRIMA-1MET induces multiple signaling pathways converging on apoptosis.Semantic proximity Read ↗

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