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Article

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans.

The Journal of clinical investigation - 1 Dec 2009

Li Hui, Xie Hui, Liu Wei, Hu Rong, Huang Bi, Tan Yan-Fei, Xu Kang, Sheng Zhi-Feng, Zhou Hou-De, Wu Xian-Ping, Luo Xiang-Hang

Abstract excerpt

MicroRNAs (miRNAs) interfere with translation of specific target mRNAs and are thought to thereby regulate many cellular processes. Recent studies have suggested that miRNAs might play a role in osteoblast differentiation and bone formation. Here, we identify a new miRNA (miR-2861) in primary mouse osteoblasts that promotes osteoblast differentiation by repressing histone deacetylase 5 (HDAC5) expression at the...

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Share to Cell Differentiation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Core Binding Factor Alpha 1 Subunit

Share to Histone Deacetylases

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Source

Open in PubMed Open full text

Identifiers

PMID: 19920351
DOI: 10.1172/JCI39832
PMCID: PMC2786801

Genes

HDAC5
BMP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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