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Article

Cloning and structural analysis of two highly divergent IgA isotypes, IgA1 and IgA2 from the duck billed platypus, Ornithorhynchus anatinus.

Molecular immunology - 1 Jan 2010

Vernersson M, Belov K, Aveskogh M, Hellman L

Abstract excerpt

To trace the emergence of modern IgA isotypes during vertebrate evolution we have studied the immunoglobulin repertoire of a model monotreme, the platypus. Two highly divergent IgA-like isotypes (IgA1 and IgA2) were identified and their primary structures were determined from full-length cDNAs. A comparative analysis of the amino acid sequences for IgA from various animal species showed that the two platypus IgA...

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PMID: 19913303
DOI: 10.1016/j.molimm.2009.10.007

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