Article
Adaptive evolution of the IgA hinge region in primates.
Molecular biology and evolution - 1 Jul 2002
Sumiyama Kenta, Saitou Naruya, Ueda Shintaroh
Abstract excerpt
IgA is a major component that prevents the penetration of pathogenic bacteria into mucosal surfaces. The IgA antibody is cleaved at the IgA hinge region with high specificity by IgA-specific proteases produced by several pathogenic bacteria. We conducted a genomic sequence analysis of the IgA genes of a wide spectrum of primates, including the first intron and second exon, which consist of the hinge region and...
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