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Article

NIK and IKKbeta interdependence in NF-kappaB signalling--flux analysis of regulation through metabolites.

Bio Systems - 1 Feb 2010

Kim Hong-Bum, Evans Iona, Smallwood Rod, Holcombe Mike, Qwarnstrom Eva E

Abstract excerpt

Activation of the transcription factor NF-kappaB is central to control of immune and inflammatory responses. Cytokine induced activation through the classical or canonical pathway relies on degradation of the inhibitor, IkappaBalpha and regulation by the IKKbeta kinase. In addition, the NF-kappaB...

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Identifiers

PMID: 19909783
DOI: 10.1016/j.biosystems.2009.10.009

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19909783-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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