Article

Computational analysis of dynamics within the Nuclear Factor-kappaB signalling system

2012-01-01

Abstract excerpt

The Nuclear Factor kappaB (NF-κB) proteins are a very important family of transcription factors. The signalling system of the NF-κB transcription factors drives cellular inflammation and immune responses, playing a central role in cell proliferation and apoptosis. NF-κB regulates the transcription of over 300 target genes including several negative feedback genes, such as the Inhibitory kappaBs (IκBs) and zinc-fin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6023c1f3-b5d0-5e33-a018-f858364b8f7f
DOI: 10.17638/00007333

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Computational analysis of dynamics within the Nuclear Factor-kappaB signalling systemDOI 10.17638/00007333Read

Circuitry of nuclear factor κB signalingSemantic proximity Read

NF‐κB regulation: the nuclear responseSemantic proximity Read

Identification and physiological significance of temporal NFκB signaling codewords deployed by macrophages to classify immune threatsSemantic proximity Read

THE NF-κB AND IκB PROTEINS: New Discoveries and InsightsSemantic proximity Read

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal IntegrationSemantic proximity Read

Introducing Spatial Information into Predictive NF-κB Modelling – An Agent-Based ApproachSemantic proximity Read

Gene regulatory logic of the interferon-β enhancer contains multiple selectively deployed modes of transcription factor synergySemantic proximity Read

Large-scale computational modelling of the M1 and M2 synovial macrophages in rheumatoid arthritisSemantic proximity Read

A computational workflow for assessing drug effects on temporal signaling dynamics reveals robustness in stimulus-specific NFκB signalingSemantic proximity Read

Large-scale computational modelling of the M1 and M2 synovial macrophages in Rheumatoid ArthritisSemantic proximity Read

The NF-κB multidimer system model: A knowledge base to explore diverse biological contextsSemantic proximity Read

NF-κB memory coordinates transcriptional responses to dynamic inflammatory stimuliSemantic proximity Read