Article
Dosage-dependent roles of the Cwt1 transcription factor for cell wall architecture, morphogenesis, drug sensitivity and virulence in Candida albicans.
Yeast (Chichester, England) - 1 Feb 2010
Moreno Inmaculada, Martinez-Esparza María, Laforet Leslie Carolina, Sentandreu Rafael, Ernst Joachim F, Valentin Eulogio
Abstract excerpt
The Cwt1 transcription factor is involved in cell wall architecture of the human fungal pathogen Candida albicans. We demonstrate here that deficiency of Cwt1 leads to decreased beta1,6-glucan in the cell wall, while mannoproteins are increased in the cell wall of exponentially growing cells and are released into the medium of stationary phase cells. Hyphal morphogenesis of cwt1 mutants is reduced on the surfaces...
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