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Article

Transcription factor Efg1 shows a haploinsufficiency phenotype in modulating the cell wall architecture and immunogenicity of Candida albicans.

Eukaryotic cell - 1 Feb 2012

Zavrel Martin, Majer Olivia, Kuchler Karl, Rupp Steffen

Abstract excerpt

The Candida albicans transcription factor Efg1 is known to be involved in many different cellular processes, including morphogenesis, general metabolism, and virulence. Here we show that besides its manifold roles, Efg1 also has a prominent effect on cell wall structure and composition, strongly affecting the structural glucan part. Deletion of only one allele of EFG1 already results in severe phenotypes for cell...

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Identifiers

PMID: 22140230
DOI: 10.1128/EC.05206-11
PMCID: PMC3272906

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