[Ring sideroblasts and iron metabolism].

Abstract excerpt

Ring sideroblasts show abnormal mitochondrial iron accumulation, and their emergence in the bone marrow is a characteristic of sideroblastic anemias (SAs). SAs are a group of heterogeneous congenital and acquired disorders. Congenital SA is a rare disease caused by gene mutations involved in heme biosynthesis, iron-sulfur cluster biosynthesis, and mitochondrial protein synthesis. SAs can also occur after exposure...

Topics

• Anemia, Sideroblastic
• Erythroid Precursor Cells
• Heme
• Humans
• Iron
• Mutation
• Myelodysplastic Syndromes