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Article

The importance of -460 C/T and +405 G/C single nucleotide polymorphisms to the function of vascular endothelial growth factor A in colorectal cancer.

Journal of cancer research and clinical oncology - 1 May 2010

Hansen Torben F, Spindler Karen-Lise G, Lorentzen Karen A, Olsen Dorte A, Andersen Rikke F, Lindebjerg Jan, Brandslund Ivan, Jakobsen Anders

Abstract excerpt

PURPOSE: The present study investigated the functional influence of the single nucleotide polymorphisms (SNPs) -460 C/T and +405 G/C at vascular endothelial growth factor A (VEGF-A), mRNA and protein levels in colorectal cancer (CRC) and normal colorectal tissue. METHODS: Blood and tissue were collected from 113 patients surgically resected for colorectal cancer. SNPs were analysed from genomic DNA by PCR, the...

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PMID: 19904558
DOI: 10.1007/s00432-009-0714-1

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