Article
Evolution of the insulin gene superfamily. Sequence of a preproinsulin-like growth factor cDNA from the Atlantic hagfish.
The Journal of biological chemistry - 5 Feb 1991
Nagamatsu S, Chan S J, Falkmer S, Steiner D F
Abstract excerpt
Complementary DNAs encoding a preproinsulin-like growth factor (prepro-IGF) have been cloned from a primitive vertebrate species, the Atlantic hagfish, by using a DNA amplification strategy based on the polymerase chain reaction. A composite sequence containing a 414-nucleotide open reading frame...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Blotting, Northern
- Cloning, Molecular
- DNA
- Genetic Variation
- Hagfishes
- Humans
- Introns
- Molecular Sequence Data
- Multigene Family
- Organ Specificity
- Polymerase Chain Reaction
- Protein Precursors
- Sequence Homology, Nucleic Acid
- Somatomedins