Article
Analysis of Recombinant Human Semenogelin as an Inhibitor of Human Sperm Motility1
4 Nov 2009
Abstract excerpt
Eppin (epididymal protease inhibitor [SPINLW1]) is present in a protein complex on the human sperm surface that contains lactotransferrin, clusterin, and semenogelin (SEMG1). During ejaculation the presence of semenogelin inhibits sperm progressive motility until semenogelin is hydrolyzed by prostate-specific antigen (PSA). Although eppin binds all three components in its protein complex, the binding of...
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