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Article

Crucial role of estrogen for the mammalian female in regulating semen coagulation and liquefaction in vivo

17 Apr 2017

Abstract excerpt

Semen liquefaction changes semen from a gel-like to watery consistency and is required for sperm to gain mobility and swim to the fertilization site in the Fallopian tubes. Kallikrein-related peptidases 3 (KLK3) and other kallikrein-related peptidases from male prostate glands are responsible for semen liquefaction by cleaving gel-forming proteins (semenogelin and collagen). In a physiological context, the...

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PMID: 28414719
DOI: 10.1371/journal.pgen.1006743

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