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Article

Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.

PloS one - 1 Jan 2013

Silva Erick J R, Hamil Katherine G, O'Rand Michael G

Abstract excerpt

Semenogelin I (SEMG1) is found in human semen coagulum and on the surface of spermatozoa bound to EPPIN. The physiological significance of the SEMG1/EPPIN interaction on the surface of spermatozoa is its capacity to modulate sperm progressive motility. The present study investigates the hypothesis that the interacting surface of SEMG1 and EPPIN co-evolved within the Hominoidea time scale, as a result of adaptive...

Read the complete abstract on PubMed

Topics

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Share to Adaptation, Physiological
Share to Binding Sites
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Peptide Fragments

Share to Proteinase Inhibitory Proteins, Secretory

Share to Selection, Genetic

Share to Sperm Motility

Share to Spermatozoa

Source

Open in PubMed Open full text

Identifiers

PMID: 24312623
DOI: 10.1371/journal.pone.0082014
PMCID: PMC3846889

Genes

EPPIN
SEMG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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