Article
Transcriptional Profiling Identifies the Signaling Axes of IGF and Transforming Growth Factor-b as Involved in the Pathogenesis of Osteosarcoma.
Clinical orthopaedics and related research - 1 Jan 2016
Yang Rui, Piperdi Sajida, Zhang Yue, Zhu Zhu, Neophytou Neophytos, Hoang Bang H, Mason Gary, Geller David, Dorfman Howard, Meyers Paul A, Healey John H, Phinney Donald G, Gorlick Richard
Abstract excerpt
BACKGROUND: Osteosarcoma is the most common primary bone tumor in adolescents associated with skeletal development. The molecular pathogenesis of osteosarcoma has not been completely determined, although many molecular alterations have been found in human osteosarcomas and cell lines. QUESTIONS/PURPOSES: We questioned whether (1) we could identify gene expression in osteosarcoma specimens that differs from normal...
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